Technology
Our own algorithms, across the entire workflow
Eighteen algorithms in production, from raw movies to ligand localisation, to speed up each step and provide you with the highest quality.
Included on all plans
Priced add-on
01 · PREPROCESSING
From raw movies to extracted particles
5 algorithms
Motion correction
CryoCloud MotionCorr
Patch-based motion correction with dose weighting, on every movie as it lands.
Included on all plans
Pre-processing
Patch-based CTF Estimation
Patch-based estimation with local defocus per micrograph.
Included on all plans
Particle picking
CryoCloud Picker
Generalised ML particle picker with higher accuracy, no per-dataset training.
Included on all plans
Particle picking
Contamination Segmentation
Masks ice, debris and support film automatically before picking.
Included on all plans
Data acquisition
Live Analysis
On-the-fly processing during data collection. First insights within 10 minutes.
Priced add-on
02 · CLASSIFICATION
Analyse heterogeneity and obtain a clean particle stack
4 algorithms
2D classification
AutoClass2D
Automated reference-based 2D class selection, no manual class picking.
Included on all plans
3D classification
AutoClass3D
Automated reference-based 3D class selection.
Included on all plans
3D classification
Automated Class3D Convergence
Stops as soon as iterations converge, saving up to 30% of runtime.
Included on all plans
Decoy classification
Automated Junk Generator
Generates decoy maps from a reference map, so junk particles sort themselves out.
Included on all plans
03 · 3D REFINEMENT
From 3D class to a high-resolution map
5 algorithms
Refinement
3D Refinement
Our proprietray 3D refinement engine
Included in all plans
Refinement
CTF Refinement
Fits defocus, astigmatism, beam tilt, aberrations and anisotropic magnification in one job, 3x faster.
Included on all plans
Masking
AutoMask Job
Masks without manual setup, ready for the next refinement round.
Included on all plans
Masking
Interactive Masking
Create focused masks with an interactive lasso tool, straight in the browser.
Included on all plans
Quality control
Anisotropy Analysis
Diagnose and quantify preferred orientation in your refined particle set.
Included on all plans
Refinement
Prune Orientations
Rebalances particle stacks to mitigate preferred orientation.
Included on all plans
04 · POSTPROCESSING
Polishing, sharpening, model building and ligand localisation
3 algorithms
Post-processing
CryoCloud Polishing
Per-particle motion refinement for the last stretch of resolution.
Included on all plans
Post-processing
Automated Map Segmentation
Given the number of subunits, a map is segmented into its subunits automatically.
Included on all plans
Post-processing
LigLoc
Systematic, unsupervised ligand localisation in cryo-EM density maps.
Priced add-on